Case report
Extracardiac rhabdomyomas – presentation of two cases with analysis of AKT/mTOR and ERK1/2 signaling
Extracardiac rhabdomyomas – presentation of two cases with analysis of AKT/mTOR and ERK1/2 signaling
Submission date: 2014-10-10
Acceptance date: 2015-02-15
Publication date: 2015-07-28
Pol J Pathol 2015;66(2):195-199
KEYWORDS
TOPICS
ABSTRACT
Extracardiac rhabdomyomas (RM) are very rare benign tumors with a poorly understood pathogenesis. In this report we describe two RM cases – a sublingual adult type tumor and a genital type tumor involving the uterine cervix. The patho-clinical characteristics, as well as the pioneer immunohistochemical analysis of ERK1/2 and AKT/mTOR pathway status is included. The expression of key proteins involved in above signaling gives new insight into the biology of extracardiac RM.
| eISSN: | 2084-9869 |
| ISSN: | 1233-9687 |
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