ORIGINAL ARTICLE
Classical autoimmune hepatitis and the IgG4-associated autoimmune hepatitis in paediatric patients
1
Department of Gastroenterology, Hepatology, Feeding Disorders and Paediatrics, The Children’s Memorial Health Institute, Warsaw, Poland
2
Department of Microbiology and Clinical Immunology, The Children’s Memorial Health Institute, Warsaw, Poland
3
Department of Pathology, The Children’s Memorial Health Institute, Warsaw, Poland
Submission date: 2024-01-10
Acceptance date: 2024-02-28
Publication date: 2024-07-08
Corresponding author
Dominika Kaps-Kopiec
Dominika Kaps-Kopiec Department of Gastroenterology, Hepatology, Feeding Disorders and Paediatrics The Children’s Memorial Health Institute Warsaw, Poland
Dominika Kaps-Kopiec Department of Gastroenterology, Hepatology, Feeding Disorders and Paediatrics The Children’s Memorial Health Institute Warsaw, Poland
Pol J Pathol 2024;75(2):153-156
KEYWORDS
TOPICS
ABSTRACT
The IgG4-associated autoimmune hepatitis (IgG4-AIH) is a newly proposed disease entity characterised by the accumulation of the IgG4-expressing plasma cells in the liver. Its pathophysiology and clinical significance remain unclear and have poor evidence in the paediatric population. Thus, our study aims at comparing the group of paediatric patients with classical AIH and the IgG4-AIH.
We carried out a retrospective analysis of 23 children (median age 8.5 years) diagnosed with AIH, who were compared according to the presence of IgG4-positive plasma cells in the liver biopsy.
IgG4-AIH was defined if 10 or more IgG4 positive plasma cells/high-power field were found in the biopsy.
The presence of the IgG4 component seems to be clinically insignificant. That is why, the conventional immunosuppressive protocol should be considered the standard treatment in the case of the IgG4-associated AIH.
We carried out a retrospective analysis of 23 children (median age 8.5 years) diagnosed with AIH, who were compared according to the presence of IgG4-positive plasma cells in the liver biopsy.
IgG4-AIH was defined if 10 or more IgG4 positive plasma cells/high-power field were found in the biopsy.
The presence of the IgG4 component seems to be clinically insignificant. That is why, the conventional immunosuppressive protocol should be considered the standard treatment in the case of the IgG4-associated AIH.
REFERENCES (9)
1.
Minaga K, Watanabe T, Chung H, et al. Autoimmune hepatitis and IgG4-related disease. World J Gastroenterol 2019; 25: 2308-2314.
2.
Chung H, Watanabe T, Kudo M, et al. Identification and characterization of IgG4-associated autoimmune hepatits. Liver Int 2010; 30: 222-231.
3.
Umemura T, Zen Y, Hamano H, et al. Clinical significance of immunoglobulin G4-associated autoimmune hepatits. J Gastroenterol 2011; 46: 48-55.
4.
Amarapurkar AD, Amarapurkar DN. Immunoglobulin IgG4 and autoimmune hepatitis. Trop Gastroenetrol 2015; 36: 112-117.
5.
Canivet CM, Anty R, Patouraux S, et al. Immunoglobulin G4-associated autoimmune hepatitis may be found in Western countries. Dig Liver Dis 2016; 48: 302-308.
6.
Aydemir Y, Akcoren Z, Demir H, et al. Clinical and histopathological feature of immunoglobulin G4-associated autoimmune hepatitis in children. J Gastroenterol Hepatol 2019; 34: 742-746.
7.
Yoshitaka A, Koshi Mat, Kazuya A, et al. Clinicopathological features of autoimmune hepatitis with IgG4-positive plasma cell infiltration. Dig Dis 2020; 39: 236-244.
8.
Norihisa Y, Masatoshi K, Hobyung C, et al. Autoimmune hepatitis and immunoglobulin G4-associated autoimmune hepatitis. Dig Dis 2013; 31: 415-420.
9.
Yunpeng L, Lifeng W. IgG4-related autoimmune hepatitis: a case report. J Internat Med Res 2023; 51: 1-6.
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| eISSN: | 2084-9869 |
| ISSN: | 1233-9687 |
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