CASE REPORT
Dermatofibroma-like granular cell tumour: a potential diagnostic pitfall
1
The Fingerland Department of Pathology, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Králové, Czech Republic
Submission date: 2016-04-09
Acceptance date: 2016-05-09
Publication date: 2016-11-25
Corresponding author
Jiri Soukup
The Fingerland Department of Pathology Charles University in Prague Faculty of Medicine and University Hospital in Hradec Kralove Sokolska 581 500 05 Hradec Králové, Czech Republic
The Fingerland Department of Pathology Charles University in Prague Faculty of Medicine and University Hospital in Hradec Kralove Sokolska 581 500 05 Hradec Králové, Czech Republic
Pol J Pathol 2016;67(3):291-294
KEYWORDS
TOPICS
ABSTRACT
Dermatofibroma-like granular cell tumour (GCT) is a rare entity, with only two cases having been described so far. We report another case in a 62-year-old woman, discuss histopathological features, and review other tumours in which granular changes have been observed. Our tumour was composed predominantly of oval-to-spindle granular cells with prominent nucleoli, arranged in short fascicles and storiform pattern, infiltrating around collagen bundles. Immunohistochemical analysis with antibodies against CD31, CD56, CD68, CD117, S-100 protein, inhibin, calretinin, EMA, p53 and MIB-1 was performed, showing expression of CD56, CD68, S-100 protein, inhibin and calretinin. The diagnosis of atypical dermatofibroma-like GCT was made.
REFERENCES (17)
1.
Miettinen M. Nerve sheath tumors. Modern soft tissue pathology: tumors and non-neoplastic conditions. Cambridge University Press, Cambridge, New York 2010; 1105.
2.
García Prats MD, López Carreira M, Martínez-González MA, et al. Granular cell basal cell carcinoma. Light microscopy, immunohistochemical and ultrastructural study. Virchows Arch A Pathol Anat Histopathol 1993; 422: 173-177.
3.
Maire G, Pedeutour F, Coindre JM. COL1A1-PDGFB gene fusion demonstrates a common histogenetic origin for dermatofibrosarcoma protuberans and its granular cell variant. Am J Surg Pathol 2002; 26: 932-937.
4.
Gleason BC, Nascimento AF. HMB-45 and Melan-A are useful in the differential diagnosis between granular cell tumor and malignant melanoma. Am J Dermatopathol 2007; 29: 22-27.
5.
Jarell A, McCalmont TH. Granular cell angiosarcoma. J Cutan Pathol 2012; 39: 476-478.
6.
Lazar AJ, Fletcher CD. Primitive nonneural granular cell tumors of skin: clinicopathologic analysis of 13 cases. Am J Surg Pathol 2005; 29: 927-934.
7.
Mentzel T, Reisshauer S, Rutten A, et al. Cutaneous clear cell myomelanocytic tumour: a new member of the growing family of perivascular epithelioid cell tumours (PEComas). Clinicopathological and immunohistochemical analysis of seven cases. Histopathology 2005; 46: 498-504.
8.
Mentzel T, Wadden C, Fletcher CD. Granular cell change in smooth muscle tumours of skin and soft tissue. Histopathology 1994; 24: 223-231.
9.
Rudisaile SN, Hurt MA, Santa Cruz DJ. Granular cell atypical fibroxanthoma. J Cutan Pathol 2005; 32: 314-317.
10.
Soyer HP, Metze D, Kerl H. Granular cell dermatofibroma. Am J Dermatopathol 1997; 19: 168-173.
11.
Fanburg-Smith JC, Meis-Kindblom JM, Fante R, et al. Malignant granular cell tumor of soft tissue: diagnostic criteria and clinicopathologic correlation. Am J Surg Pathol 1998; 22: 779-794.
12.
Cheng SD, Usmani AS, DeYoung BR, et al. Dermatofibroma-like granular cell tumor. J Cutan Pathol 2001; 28: 49-52.
13.
Hong SB, Yang MH, Lee MH, et al. Dermatofibroma-like atypical granular cell tumour. Acta Derm Venereol 2005; 85: 179-180.
14.
Shintaku M. Immunohistochemical localization of autophagosomal membrane-associated protein LC3 in granular cell tumor and schwannoma. Virchows Arch 2011; 459: 315-319.
15.
Mahalingam M, LoPiccolo D, Byers HR. Expression of PGP 9.5 in granular cell nerve sheath tumors: an immunohistochemical study of six cases. J Cutan Pathol 2001; 28: 282-286.
16.
Fine SW, Li M. Expression of calretinin and the alpha-subunit of inhibin in granular cell tumors. Am J Clin Pathol 2003; 119: 259-264.
17.
Battistella M, Cribier B, Feugeas JP, et al. Vascular invasion and other invasive features in granular cell tumours of the skin: a multicentre study of 119 cases. J Clin Pathol 2014; 67: 19-25.
| eISSN: | 2084-9869 |
| ISSN: | 1233-9687 |
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