ORIGINAL ARTICLE
Expression of β-catenin and its correlation with metastatic progression of esophagogastric junction adenocarcinoma
Publication date: 2016-02-05
Pol J Pathol 2015;66(4):414-419
KEYWORDS
ABSTRACT
The evaluation of β-catenin expression in adenocarcinoma of the esophagogastric junction and its influence on cancer progression.
Sixty-one patients who were diagnosed with adenocarcinoma of the esophagogastric junction were examined. We evaluated β-catenin distribution in the cell membrane and the cell nucleus in adenocarcinoma of the esophagogastric junction type 1 and type 3.
Our findings showed lack of a statistically significant difference in evaluation of adenocarcinoma type 1 and type 3 aggressiveness. However, we found a statistically significant association with the T and N stage, although we did not find an effect of them on patient survival.
Patients with cellular membrane and cell nucleus staining comprise a group of patients with higher risk of malignancy progression in adenocarcinoma of the esophagogastric junction types 1 and 3.
Sixty-one patients who were diagnosed with adenocarcinoma of the esophagogastric junction were examined. We evaluated β-catenin distribution in the cell membrane and the cell nucleus in adenocarcinoma of the esophagogastric junction type 1 and type 3.
Our findings showed lack of a statistically significant difference in evaluation of adenocarcinoma type 1 and type 3 aggressiveness. However, we found a statistically significant association with the T and N stage, although we did not find an effect of them on patient survival.
Patients with cellular membrane and cell nucleus staining comprise a group of patients with higher risk of malignancy progression in adenocarcinoma of the esophagogastric junction types 1 and 3.
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| eISSN: | 2084-9869 |
| ISSN: | 1233-9687 |
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