CASE REPORT
Quiz CORRECT ANSWER TO THE QUIZ. CHECK YOUR DIAGNOSIS
Prostatic paraganglia-hyperplasia – a histological mimic of intraprostatic adipose tissue
1
Department of General and Clinical Pathology, Medical University of Plovdiv, Bulgaria
2
Department of Forensic Medicine, Medical University of Plovdiv, Bulgaria
3
Department of Pathology, Military Medical Academy, Sofia, Bulgaria
4
Department of Pathology, Jossigny Hospital, Jossigny, France
Publication date: 2024-07-10
Corresponding author
Maria Koleva
Maria Koleva, PhD Department of General and Clinical Pathology Medical University of Plovdiv Plovdiv, Bulgaria
Maria Koleva, PhD Department of General and Clinical Pathology Medical University of Plovdiv Plovdiv, Bulgaria
Pol J Pathol 2024;75(3):256-258
ABSTRACT
Prostatic paraganglia (PP) can simulate adenocarcinoma’s fused gland pattern, and a differential diagnostic panel is developed. Their differential diagnosis with benign prostatic lesions has been largely unreported.
Intraprostatic adipose tissue (IPAT) is seen extremely rarely in prostatic specimens, but it must be known, to avoid false positive results for extraprostatic fat carcinomatous invasion in needle biopsy specimens.
We present one case from 100 randomly selected radical prostatectomy specimens in which our diagnosis evolved from IPAT to PP-hyperplasia, after additional immunohistochemical investigations. The presence of PP-hyperplasia, with both parenchymal and neurovascular bundle location, and its differential diagnosis with IPAT has not been previously reported.
Intraprostatic adipose tissue (IPAT) is seen extremely rarely in prostatic specimens, but it must be known, to avoid false positive results for extraprostatic fat carcinomatous invasion in needle biopsy specimens.
We present one case from 100 randomly selected radical prostatectomy specimens in which our diagnosis evolved from IPAT to PP-hyperplasia, after additional immunohistochemical investigations. The presence of PP-hyperplasia, with both parenchymal and neurovascular bundle location, and its differential diagnosis with IPAT has not been previously reported.
REFERENCES (9)
1.
Ostrowski ML, Wheeler TM. Paraganglia of the prostate. Location, frequency, and differentiation from prostatic adenocarcinoma. Am J Surg Pathol 1994; 18: 412-420.
2.
Srigley JR. Benign mimickers of prostatic adenocarcinoma. Mod Pathol 2004; 17: 328-348.
3.
Kawabata K. Paraganglion of the prostate in a needle biopsy: a potential diagnostic pitfall. Arch Pathol Lab Med 1997; 121: 515-516.
6.
Joshi A, Shah V, Varma M. Intraprostatic fat in a prostatic needle biopsy : a case report and review of the literature. Histopathology 2009; 54: 912-913.
7.
Nazeer T, Kee KH, Ro JY, et al. Intraprostatic adipose tissue : a study of 427 whole mount radical prostatectomy specimens. Hum Pathol 2009; 40: 538-541.
8.
Gellert LL. Hyperplasia-paraganglia. Available from: https://www.pathologyoutlines.... (accessed: 22.10.2022).
9.
So JS, Epstein JI. GATA3 expression in paragangliomas: a pitfall potentially leading to misdiagnosis of urothelial carcinoma. Mod Pathol 2013; 26: 1365-1370.
| eISSN: | 2084-9869 |
| ISSN: | 1233-9687 |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
