ORIGINAL ARTICLE
Up-regulated lncRNA LINC00858 facilitates proliferation and migration of gastric cancer cells
1
Department of General Surgery, The First People’s Hospital of Huzhou, Zhejiang Province, China
2
Department of General Surgery, Wuxing District People’s Hospital, Huzhou City, Zhejiang Province, China
Submission date: 2019-08-15
Final revision date: 2020-01-12
Acceptance date: 2020-06-30
Publication date: 2020-10-25
Pol J Pathol 2020;71(3):236-243
KEYWORDS
TOPICS
ABSTRACT
Previous evidence has shown that the long intergenic non-protein coding RNA 858 (LINC00858) is an oncogene in non-small cell lung cancers. However, the role LINC00858 plays in gastric cancer (GC) is not clear. To illustrate the role LINC00858 plays in GC, the LINC00858 expression in GC and normal tissues was firstly detected. Then, the viability, proliferation and migration of GC BGC823 and MGC803 cells were assessed following LINC00858 knockdown by si-LINC00858 transfection. The results showed that LINC00858 had a high level of expressions in GC tissues as demonstrated by both online data and qRT-PCR assay. Also, the knockdown of LINC00858 reduced the proliferation and migration of BGC823 and MGC803 cells in vitro. Taken together, our data indicate that LINC00858 plays an oncogenic role in GC cells and might act as a potential therapeutic target for GC.
REFERENCES (37)
1.
Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2018; 68: 394-424.
2.
Van Cutsem E, Sagaert X, Topal B, et al. Gastric cancer. Lancet 2016; 388: 2654-2664.
3.
McLean MH, El-Omar EM. Genetics of gastric cancer. Nat Rev Gastroenterol Hepatol 2014; 11: 664-674.
4.
Padmanabhan N, Ushijima T, Tan P. How to stomach an epigenetic insult: the gastric cancer epigenome. Nat Rev Gastroenterol Hepatol 2017; 14: 467-478.
5.
Ajani JA, Lee J, Sano T, et al. Gastric adenocarcinoma. Nat Rev Dis Primers 2017; 3: 17036.
6.
Hierro C, Alsina M, Sanchez M, et al. Targeting the fibroblast growth factor receptor 2 in gastric cancer: promise or pitfall? Ann Oncol 2017; 28: 1207-1216.
7.
Uszczynska-Ratajczak B, Lagarde J, Frankish A, et al. Towards a complete map of the human long non-coding RNA transcriptome. Nat Rev Genet 2018; 19: 535-548.
8.
Kopp F, Mendell JT. Functional Classification and experimental dissection of long noncoding RNAs. Cell 2018; 172: 393-407.
9.
Ramanathan M, Porter DF, Khavari PA. Methods to study RNA-protein interactions. Nat Methods 2019; 16: 225-234.
10.
Esposito R, Bosch N, Lanzos A, et al. Hacking the cancer genome: profiling therapeutically actionable long non-coding RNAs using CRISPR-Cas9 screening. Cancer Cell 2019; 35: 545-557.
11.
Beermann J, Piccoli MT, Viereck J, Thum T. Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. Physiol Rev 2016; 96: 1297-1325.
12.
Sun TT, He J, Liang Q, et al. LncRNA GClnc1 promotes gastric carcinogenesis and may act as a modular scaffold of WDR5 and KAT2A complexes to specify the histone modification pattern. Cancer Discov 2016; 6: 784-801.
13.
Zhuo W, Liu Y, Li S, et al. Long noncoding RNA GMAN, up-regulated in gastric cancer tissues, is associated with metastasis in patients and promotes translation of ephrin A1 by competitively binding GMAN-AS. Gastroenterology 2019; 156: 676-691.
14.
Yu Y, Yang J, Li Q, et al. LINC00152: A pivotal oncogenic long non-coding RNA in human cancers. Cell Prolif 2017; 50: e12349.
15.
Chen B, Zhao Q, Guan L, et al. Long non-coding RNA NNT-AS1 sponges miR-424/E2F1 to promote the tumorigenesis and cell cycle progression of gastric cancer. J Cell Mol Med 2018; 22: 4751-4759.
16.
Li JF, Li WH, Xue LL, Zhang Y. Long non-coding RNA PICART1 inhibits cell proliferation by regulating the PI3K/AKT and MAPK/ERK signaling pathways in gastric cancer. Eur Rev Med Pharmacol Sci 2019; 23: 588-597.
17.
Tam C, Wong JH, Tsui S, et al. LncRNAs with miRNAs in regulation of gastric, liver, and colorectal cancers: updates in recent years. Appl Microbiol Biotechnol 2019; 103: 4649-4677.
18.
Xue M, Shi D, Xu G, Wang W. The long noncoding RNA linc00858 promotes progress of lung cancer through miR-3182/MMP2 axis. Artif Cells Nanomed Biotechnol 2019; 47: 2091-2097.
19.
Zhu SP, Wang JY, Wang XG, Zhao JP. Long intergenic non-protein coding RNA 00858 functions as a competing endogenous RNA for miR-422a to facilitate the cell growth in non-small cell lung cancer. Aging (Albany NY) 2017; 9: 475-486.
20.
Gu Z, Hou Z, Zheng L, et al. Long noncoding RNA LINC00858 promotes osteosarcoma through regulating miR-139-CDK14 axis. Biochem Biophys Res Commun 2018; 503: 1134-1140.
21.
Sha QK, Chen L, Xi JZ, Song H. Long non-coding RNA LINC00858 promotes cells proliferation, migration and invasion by acting as a ceRNA of miR-22-3p in colorectal cancer. Artif Cells Nanomed Biotechnol 2019; 47: 1057-1066.
22.
Xu TP, Huang MD, Xia R, et al. Decreased expression of the long non-coding RNA FENDRR is associated with poor prognosis in gastric cancer and FENDRR regulates gastric cancer cell metastasis by affecting fibronectin1 expression. J Hematol Oncol 2014; 7: 63.
23.
Leucci E. Cancer development and therapy resistance: spotlights on the dark side of the genome. Pharmacol Ther 2018; 189: 22-30.
24.
Hu X, Sood AK, Dang CV, Zhang L. The role of long noncoding RNAs in cancer: the dark matter matters. Curr Opin Genet Dev 2018; 48: 8-15.
25.
Sun Y, Ma L. New insights into long non-coding RNA MALAT1 in cancer and metastasis. Cancers (Basel) 2019; 11: 216.
26.
Feeley KP, Edmonds MD. Hiding in Plain sight: rediscovering the importance of noncoding RNA in human malignancy. Cancer Res 2018; 78: 2149-2158.
27.
Bhan A, Soleimani M, Mandal SS. Long noncoding RNA and cancer: a new paradigm. Cancer Res 2017; 77: 3965-3981.
28.
Lian Y, Yang J, Lian Y, et al. DUXAP8, a pseudogene derived lncRNA, promotes growth of pancreatic carcinoma cells by epigenetically silencing CDKN1A and KLF2. Cancer Commun (Lond) 2018; 38: 64.
29.
Fang Y, Fullwood MJ. Roles, functions, and mechanisms of long non-coding RNAs in cancer. Genomics Proteomics Bioinformatics 2016; 14: 42-54.
30.
Lian Y, Li Z, Fan Y, et al. The lncRNA-HOXA-AS2/EZH2/LSD1 oncogene complex promotes cell proliferation in pancreatic cancer. Am J Transl Res 2017; 9: 5496-5506.
31.
Hu B, Wang X, Li L. Long noncoding RNA LINC00337 promote gastric cancer proliferation through repressing p21 mediated by EZH2. Am J Transl Res 2019; 11: 3238-3245.
32.
Zhang Y, Miao Y, Shang M, et al. LincRNA-p21 leads to G1 arrest by p53 pathway in esophageal squamous cell carcinoma. Cancer Manag Res 2019; 11: 6201-6214.
33.
Gan L, Xu M, Zhang Y, et al. Focusing on long noncoding RNA dysregulation in gastric cancer. Tumour Biol 2015; 36: 129-141.
34.
Sun W, Yang Y, Xu C, et al. Roles of long noncoding RNAs in gastric cancer and their clinical applications. J Cancer Res Clin Oncol 2016; 142: 2231-2237.
35.
Zong W, Ju S, Jing R, Cui M. Long non-coding RNA-mediated regulation of signaling pathways in gastric cancer. Clin Chem Lab Med 2018; 56: 1828-1837.
36.
Tong J, Ma X, Yu H, Yang J. SNHG15: a promising cancer-related long noncoding RNA. Cancer Manag Res 2019; 11: 5961-5969.
37.
Wang F, Liang S, Liu X, et al. LINC00460 modulates KDM2A to promote cell proliferation and migration by targeting miR-342-3p in gastric cancer. Onco Targets Ther 2018; 11: 6383-6394.
Share
RELATED ARTICLE
| eISSN: | 2084-9869 |
| ISSN: | 1233-9687 |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
