ORIGINAL ARTICLE
Activation of the P38-MSK1 axis in colorectal adenocarcinoma determines a good prognostic outcome
1
Assistant professor of Pathology, Faculty of Medicine, Minia University, Minia, Egypt
2
Consultant of Onco-surgery, Minia Oncology Centre, Minia, Egypt
3
Assistant professor of Tropical Medicine, Faculty of Medicine, Minia University, Minia, Egypt
4
Biomedical Scientist, UCL Institute for Liver and Digestive Health, Royal Free London NHS Foundation Trust, London, UK
Submission date: 2020-09-25
Final revision date: 2020-11-04
Acceptance date: 2020-11-16
Publication date: 2021-05-31
Pol J Pathol 2021;72(1):39-47
KEYWORDS
TOPICS
ABSTRACT
Colorectal cancer (CRC) is the third most common cancer worldwide and is associated with a high level of mortality and morbidity. In this study we evaluate expression of p-p38 and p-MSK1 in CRC and determine whether there is an association between expression of these markers and any clinicopathologic parameters that could be of prognostic value.
Expression of p-p38, p-MSK1 and ki-67 were examined by immunohistochemistry in 135 archival CRC cases and the findings were correlated with the patient clinicopathological data.
P-p38 and p-MSK1 were expressed at high level in 58.5 % and 60.7% of CRC cases respectively. A statistically significant negative correlation was found between expression of p-p38 and Ki-67 (p < 0.001, r = –0.63) and between p-MSK1 and Ki-67 expression (p < 0.001, r = –0.61). The majority of CRC cases expressing high levels of p-p38 also expressed high levels of p-MSK1 and this correlation was highly significant (p < 0.001, r = 0.863). The high expression of p-p38 and p-MSK1 was also significantly associated with low Dukes and TNM stage. The elevated expression of p-38 and p-MSK1 in CRC was associated with a good prognosis and prolonged overall survival (p < 0.001, each).
Our finding showed that activation of the p38-MSK1 axis determines a good outcome in CRC.
Expression of p-p38, p-MSK1 and ki-67 were examined by immunohistochemistry in 135 archival CRC cases and the findings were correlated with the patient clinicopathological data.
P-p38 and p-MSK1 were expressed at high level in 58.5 % and 60.7% of CRC cases respectively. A statistically significant negative correlation was found between expression of p-p38 and Ki-67 (p < 0.001, r = –0.63) and between p-MSK1 and Ki-67 expression (p < 0.001, r = –0.61). The majority of CRC cases expressing high levels of p-p38 also expressed high levels of p-MSK1 and this correlation was highly significant (p < 0.001, r = 0.863). The high expression of p-p38 and p-MSK1 was also significantly associated with low Dukes and TNM stage. The elevated expression of p-38 and p-MSK1 in CRC was associated with a good prognosis and prolonged overall survival (p < 0.001, each).
Our finding showed that activation of the p38-MSK1 axis determines a good outcome in CRC.
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