Blue nevus presenting as an endocervical polyp
Publication date: 2016-08-02
Pol J Pathol 2016;67(2):191-194
KEYWORDS
ABSTRACT
We report herein a case of blue nevus of the uterine cervix presenting as an endocervical polyp. A 58-year-old Japanese female was presented with an endocervical polyp. The polyp was promptly excised, and histological examination revealed distribution of many melanin-loaded spindle-shaped cells in its stromal portion. Immunohistochemically, the cells were positive for S100 protein, SOX10, HMB45, and MART-1. Based on the characteristic cellular morphology and immunohistochemical findings, the lesion was diagnosed as a blue nevus, and malignant melanoma was denied. Endocervical blue nevi are relatively rare, and there are some discordance among previous publications about immunoreactivity against HMB45 and MART-1.
REFERENCES (17)
1.
Hagiwara T, Kaku T, Kobayashi H, et al. Coexisting vulvar malignant melanoma and blue nevus of the cervix. Gynecol Oncol 2005; 99: 519-520.
2.
Zevallos-Giampietri EA, Barrionuevo C. Common blue nevus of the uterine cervix: case report and review. Appl Immunohistochem Mol Morphol 2004; 12: 79-82.
3.
Handa U, Mohan H, Garg S. Incidental detection of pigmented lesions in the cervix. Aust N Z J Obstet Gynaecol 2007; 47: 254-255.
4.
Szumi³o J, Patel A, Patel S, et al. Blue nevus of the endocervix. Folia Morphol (Warsz) 2010; 69: 62-64.
5.
Eskue K, Prieto VG, Malpica A. Cellular blue nevus of the uterus: a case report and review of the literature. Int J Gynecol Pathol 2010; 29: 583-586.
6.
Parada D, Pe¼a KB, Riu F. Coexisting malignant melanoma and blue nevus of the uterine cervix: an unusual combination. Case Rep Pathol 2012; 2012: 986542.
7.
Ishida M, Kagotani A, Yoshida K, et al. Endometrioid adenocarcinoma concurrent with a blue nevus of the endometrium and uterine cervix: A case report. Oncol Lett 2013; 6: 1219-1221.
8.
Craddock KJ, Bandarchi B, Khalifa MA. Blue nevi of the Müllerian tract: case series and review of the literature. J Low Genit Tract Dis 2007; 11: 284-289.
9.
Tran TA, Niu G, Tomasello CA, et al. The spectrum of grossly visible pigmented lesions in the uterine cervix: a prospective study. Int J Gynecol Pathol 2014; 33: 89-99.
10.
Nucci MR, Carcangiu ML, Ferry JA, et al. Melanocytic tumours. In: Kurman RJ, et al. (eds.). WHO Classification of Tumours of Female Reproductive Organs, 4th ed. Lyon: International Agency for Research on Cancer 2014: 204.
11.
Uehara T, Izumo T, Kishi K, et al. Stromal melanocytic foci (“blue nevus”) in step sections of the uterine cervix. Acta Pathol Jpn 1991; 41: 751-756.
12.
Uehara T, Takayama S, Takemura T, et al. Foci of stromal melanocytes (so-called blue naevus) of the uterine cervix in Japanese women. Virchows Arch A Pathol Anat Histopathol 1991; 418: 327-331.
13.
Elder DE, Elenitsas R, Murphy GF, et al. Blue nevi. In: Elder DE (ed.). Lever’s Histopathology of the Skin. 11th ed. Wolters Kluwer, Philadelphia 2015; 856-861.
14.
Nonaka D, Chiriboga L, Rubin BP. Sox10: a pan-schwannian and melanocytic marker. Am J Surg Pathol 2008; 32: 1291-1298.
15.
Ishikura H, Kojo T, Ichimura H, et al. Desmoplastic malignant melanoma of the uterine cervix: a rare primary malignancy in the uterus mimicking a sarcoma. Histopathology 1998; 33: 93-94.
16.
Taatjes DJ, Arendash-Durand B, von Turkovich M, et al. HMB-45 antibody demonstrates melanosome specificity by immunoelectron microscopy. Arch Pathol Lab Med 1993; 117: 264-268.
17.
Schaumburg-Lever G. The alkaline phosphatase anti-alkaline phosphatase technique in dermatopathology. J Cutan Pathol 1987; 14: 6-9.
Share
RELATED ARTICLE
| eISSN: | 2084-9869 |
| ISSN: | 1233-9687 |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
