ORIGINAL ARTICLE
Comparison of the ICC location in the gallbladder wall in patients with cholelithiasis and patients with non-calculous changes
1
Department of Pathomorphology and Oncological Cytology, Wroclaw Medical University, Poland
Submission date: 2018-08-05
Final revision date: 2019-01-25
Acceptance date: 2019-06-02
Publication date: 2019-12-08
Pol J Pathol 2019;70(3):205-209
KEYWORDS
TOPICS
ABSTRACT
Interstitial cells of Cajal (ICC) were first described by Santiago Ramon y Cajal over 100 years ago. They are thought to play an important role in the regulation of gastrointestinal motility. There is increasing evidence that the decline in their number in the gallbladder wall contributes to the formation of concrements. The aim of the study was to determine the exact location of interstitial cells of Cajal in the gallbladder wall in patients with calculous and non-calculous cholecystitis. Sixty-eight patients were examined, of whom 50 were cases of cholelithiasis and 18 were of non-calculous cholecystitis. The technique of immunohistochemistry with the CD117 antibody was used to determine the cells of Cajal, while to distinguish them from mast cells the technique with mast cell tryptase (MCT) was applied. Redistribution of the interstitial cells of Cajal from the muscle membrane to lamina propria of mucous tissue was observed in the cases of cholelithiasis, while in the group of non-calculous cholecystitis most of the ICC was located within the muscle tissue.
REFERENCES (25)
1.
Pasternak A, Szura M, Gil K, et al. Interstitial cells of Cajal - systematic review. Folia Morphol 2016; 75: 281-286.
2.
Baker SA, Drumm BT, Skowronek KE, et al. Excitatory Neuronal Responses of Ca 2+ Transients in Interstitial Cells of Cajal in the Small Intestine. Eneuro 2018; 5; 1-22.
3.
Lavoie B, Balemba OB, Nelson MT, et al. Morphological and physiological evidence for interstitial cell of Cajal-like cells in the guinea pig gallbladder. J Physiol 2007; 579: 487-501.
4.
Fan Y, Wu S, Fu B, et al. The role of interstitial Cajal-like cells in the formation of cholesterol stones in guinea pig gallbladder. Hepatol Int 2015; 9: 612-620.
5.
Ahmadi O, de L Nicholson M, Gould ML, et al. Interstitial cells of Cajal are present in human extrahepatic bile ducts. J Gastroenterol Hepatol 2010; 25: 277-285.
6.
Popescu LM, Ciontea SM, Cretoiu D, et al. Interstitial Cajal-like cells in human uterus and fallopian tube. Ann N Y Acad. Sci 2007; 1101: 139-165.
7.
Pasternak A, Gil K, Matyja A, et al. Loss of gallbladder interstitial Cajal-like cells in patients with cholelithiasis. Neurogastroenterol Motil 2013; 25: 17-24.
8.
Pilecki W, Koleda P, Nature of Interstitial Cells of Cajal of the Upper Urinary Tract. Adv Clin Exp Med 2014; 23: 627-632.
9.
Iino S, Horiguchi K, Interstitial Cells of Cajal Are Involved in Neurotransmission in the Gastrointestinal Tract. Acta Histochem Cytochem 2006; 39: 145-153.
10.
Hanani M, Farrugia G, Komuro T, et al. Intercellular coupling of interstitial cells of cajal in the digestive tract. Int Rev Cytol 2004; 242: 249-282.
11.
Xu D, Yu BP, Luo HS, et al. Control of gallbladder contractions by cholecystokinin through cholecystokinin-A receptors on gallbladder interstitial cells of cajal. World J Gastroenterol 2008; 14: 2882-2887.
12.
Beckett EAH, Horiguchi K, Khoyi M, et al. Loss of enteric motor neurotransmission in the gastric fundus of Sl/Sldmice. J Physiol 2002; 543: 871-887.
13.
Pasternak A, Szura M, Mazur M, et al. Number and Distribution of Interstitial Cells of Cajal in Human Gallbladder. Folia Med Cracov 2014; 1: 71-77.
14.
Apoznanski W, Koleda P, Wozniak Z, et al. The distribution of interstitial cells of Cajal in congenital ureteropelvic junction obstruction. Int Urol Nephrol 2013; 45: 607-612.
15.
Mendoza-Marin M, Hoang MP, Albores-Saavedra J, et al. Malignant stromal tumor of the gallbladder with interstitial cells of Cajal phenotype. Arch Pathol Lab Med 2002; 126: 481-483.
16.
Portincasa P, Di Ciaula A, Vendemiale, et al. Gallbladder motility and cholesterol crystallization in bile from patients with pigment and cholesterol gallstones. Eur J Clin Invest 2000; 30: 317-324.
17.
Gibbons SJ, De Giorgio R, Faussone Pellegrini MS, et al. Apoptotic cell death of human interstitial cells of Cajal. Neurogastroenterol Motil 2009; 21: 85-93.
18.
Iino S, Horiguchi S, Horiguchi K, et al. Interstitial cells of Cajal in the gastrointestinal musculature of W jic c-kit mutant mice. J Smooth Muscle Res 2011; 47: 111-121.
19.
Galeazzi F, Haapala EM, van Rooijen N, et al. Inflammation-induced impairment of enteric nerve function in nematode-infected mice is macrophage dependent. Am J Physiol Gastrointest Liver Physiol 2000; 278: G259-G265.
20.
Negreanu LM, Assor P, Mateescu B, et al. Interstitial cells of Cajal in the gut – A gastroenterologist’s point of view. World J Gastroenterol 2008; 14: 6285-6288.
21.
Forster J, Damjanov I, Lin Z, et al. Absence of the interstitial cells of Cajal in patients with gastroparesis and correlation with clinical findings. J Gastrointest Surg 2005; 9: 102-108.
22.
Pasternak A, Gajda M, Gil K, et al. Evidence of interstitial Cajal-like cells in human gallbladder. Folia Histochem Cytobiol 2012; 50: 581-585.
23.
Suzuki T, Kyung-Jong W, Horiguchi K, et al. Muscularis inflammation and the loss of interstitial cells of Cajal in the endothelin ETB receptor null rat. AJP Gastrointest Liver Physiol 2004; 287: G638-G646.
24.
Kasprzak AA, Szmyt M, Malkowski W, et al. Expression of phenotypic markers of mast cells, macrophages and dendritic cells in gallbladder mucosa with calculous cholecystitis. Polish J Pathol 2013; 64: 281-289.
25.
Hinescu ME, Ardeleanu C, Gherghiceanu M, et al. Interstitial Cajal-like cells in human gallbladder. J Mol Histol 2007; 38: 275-284.
| eISSN: | 2084-9869 |
| ISSN: | 1233-9687 |
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