CASE REPORT
Dedifferentiated endometrial carcinoma: an ongoing diagnostic dilemma
Submission date: 2018-01-04
Acceptance date: 2018-01-07
Publication date: 2018-07-06
Pol J Pathol 2018;69(2):195-199
KEYWORDS
dedifferentiated endometrial carcinomaendometrial carcinomaendometrioid carcinoma undifferentiated carcinomaimmunohistochemistry
TOPICS
ABSTRACT
Tumours of uterine corpus are the most common gynaecological malignancies. The clinicopathological features of most of these tumours are well understood; however, dedifferentiated endometrial carcinoma still requires a lot of research to establish adequate management guidelines. The entity was first described in 2006 and is an aggressive tumour with poor prognosis. We present two cases of this tumour with a literature review, emphasising morphologic and immunohistochemical features that may help in the differential diagnosis.
REFERENCES (20)
1.
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2016. CA Cancer J Clin 2016; 66: 7-30.
2.
Benedet JL, Bender H, Jones H 3rd, et al. FIGO staging classifications and clinical practice guidelines of gynaecologic cancers. Int J Gynecol Obstet 2000; 70: 209-262.
3.
Silva EG, Deavers MT, Bodurka DC, et al. Association of low-grade endometrioid carcinoma of the uterus and ovary with undifferentiated carcinoma: a new type of dedifferentiated carcinoma? Int J Gynecol Pathol 2006; 25: 52-58.
4.
Han J, Ki EY, Rha SE, et al. Dedifferentiated endometrioid carcinoma of the uterus: report of four cases and review of literature. World J Surg Oncol 2017; 15: 17.
5.
Li Z, Zhao C. Clinicopathologic and immunohistochemical characterization of dedifferentiated endometrioid adenocarcinoma. Appl Immunohistochem Mol Morphol 2016; 24: 562-568.
6.
Tafe LJ, Garg K, Chew I, et al. Endometrial and ovarian carcinomas with undifferentiated components: clinically aggressive and frequently underrecognized neoplasms. Mod Pathol 2010; 23: 781-789.
7.
Mouka V, Tsili AC, Messinis T, et al. Solitary adrenal metastasis from early-stage dedifferentiated endometrial carcinoma: CT findings and review of the literature. J Obstet Gynaecol 2016; 36: 881-882.
8.
Berretta R, Patrelli TS, Faioli R, et al. Dedifferentiated endometrial cancer: an atypical case diagnosed from cerebellar and adrenal metastasis: case presentation and review of literature. Int J Clin Exp Pathol 2013; 6: 1652-1657.
9.
Stewart CJ, Crook ML. SWI/SNF complex deficiency and mismatch repair protein expression in undifferentiated and dedifferentiated endometrial carcinoma. Pathology 2015; 47: 439-445.
10.
Karnezis AN, Hoang LN, Coatham M, et al. Loss of switch/sucrose non-fermenting complex protein expression is associated with dedifferentiation in endometrial carcinomas. Mod Pathol 2016; 29: 302-314.
11.
Strehl JD, Wachter DL, Fiedler J, et al. Pattern of SMARCB1 (INI1) and SMARCA4 (BRG1) in poorly differentiated endometrioid adenocarcinoma of the uterus: analysis of a series with emphasis on a novel SMARCA4-deficient dedifferentiated rhabdoid variant. Ann Diagn Pathol 2015; 19: 198-202.
12.
Altrabulsi B, Malpica A, Bodurka DC, et al. Undifferentiated carcinoma of the endometrium. Am J Surg Pathol 2005; 10: 1316Y21.
13.
Silva EG, Deavers MT, Malpica A. Undifferentiated carcinoma of the endometrium: a review. Pathology 2007; 39: 134-138.
14.
Ramalingam P, Masand RP, Euscher ED, et al. Undifferentiated carcinoma of the endometrium: an expanded immunohistochemical analysis including PAX-8 and basal-like carcinoma surrogate markers. Int J Gynecol Pathol 2016; 35: 410-418.
15.
Shen Y, Wang Y, Shi Y, et al. Clinicopathologic study of endometrial dedifferentiated endometrioid adenocarcinoma: a case report. Int J Clin Exp Pathol 2012; 5: 77-82.
16.
Hoang LN, Lee YS, Karnezis AN, et al. Immunophenotypic features of dedifferentiated endometrial carcinoma – insights from BRG1/INI1-deficient tumors. Histopathology 2016; 69: 560-569.
17.
Sakuragi N, Nishiya M, Ikeda K, et al. Decreased E-cadherin expression in endometrial carcinoma is associated with tumor dedifferentiation and deep myometrial invasion. Gynecol Oncol 1994; 53: 183-189.
18.
Stewart CJ, Crook ML. Fascin expression in undifferentiated and dedifferentiated endometrial carcinoma. Hum Pathol 2015; 46: 1514-1520.
19.
Onder S, Taskin OC, Sen F, et al. High expression of SALL4 and fascin, and loss of E-cadherin expression in undifferentiated/dedifferentiated carcinomas of the endometrium: An immunohistochemical and clinicopathologic study. Medicine (Baltimore) 2017; 96: e6248.
20.
Garg K, Leitao MM Jr, Kauff ND, et al. Selection of endometrial carcinomas for DNA mismatch repair protein immunohistochemistry using patient age and tumor morphology enhances detection of mismatch repair abnormalities. Am J Surg Pathol 2009; 33: 925-933.
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| eISSN: | 2084-9869 |
| ISSN: | 1233-9687 |
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