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Primary angiosarcoma of the vulva: report of a case misdiagnosed as a benign tumor
 
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1
Department of Pathology, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Romania
 
2
Department of Cardiology, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Romania
 
3
Department of Pathology, Emergency Hospital, Targu Mures, Romania
 
4
Department of Pathology, Emergency County Hospital Sfantu Gheorghe, Romania
 
5
Department of Gynecology and Obstetrics, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Romania
 
 
Submission date: 2021-03-18
 
 
Acceptance date: 2021-04-25
 
 
Publication date: 2021-09-30
 
 
Pol J Pathol 2021;72(2):167-169
 
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ABSTRACT
Primary vulvar angiosarcomas have a propensity for varied macroscopic and histologic appearance that initially may not suggest a vascular malignant neoplasm. Therefore, the rarity of the lesion and it’s morphologic diversity may contribute to the high rate of misdiagnosis. We present the case of a 43-year old patient with a primary vulvar lesion, initially misdiagnosed as an angiofibroma. Microscopic examination of the recurrence together with immunohistochemical profile were in favor on a poorly differentiated angiosarcoma. Early diagnoses can improve prognoses in angiosarcomas and, in the case of recurrences, as in the present case, may lead to changes in therapy.
REFERENCES (10)
1.
Young RJ, Brown NJ, Reed MW, et al. Angiosarcoma. Lancet Oncol 2010; 11: 983-991.
 
2.
Davos I, Abell MR. Soft tissue sarcomas of vulva. Gynecol Oncol 1976; 4: 70-86.
 
3.
Nirenberg A, Ostor AG, Slavin J, et al. Primary vulvar sarcomas. Int J Gynecol Pathol 1995; 14: 55-62.
 
4.
Kruse AJ, Sep S, Slangen BFM, et al. Angiosarcomas of primary gynecologic origin. A clinicopathologic review and quantitative analysis of survival. Int J Gynecol Cancer 2014; 24: 4-12.
 
5.
Sheinis M, Cesari M, Selk A. Angiosarcoma of the vulva; a case report. J Lower Gen Tract Dis 2016; 20: e6-e7.
 
6.
Yost S, Bradish J, Grossheim L, et al. Epithelioid anfiosarcoma of the vulva: a case report. Gynecologic Oncol Reports 2017; 91-93.
 
7.
Laliscia C, Gadducci A, Pollina LE, et al. Angiosarcoma after adjuvant radiotherapy in high-risk squamous cell carcinoma of the vulva: a case report. Menopause Rev 2019; 18: 230-232.
 
8.
Meyer M, Smith ES, Leitao MM. Angiosarcoma of the vulva following readiation for colorectal cancer. Gynecologic Oncol Reports 2021; 36: 100711.
 
9.
Franzcog SH, Uitterhoeve LJ, Schilthuis MS, et al. Sarcoma in association with multimodality management of vulvar cancer: tow case reprts. Gynecol Oncol 2001; 81: 320-323.
 
10.
Hart J, Mandavilli S. Epithelioid angiosarcoma: a brief diagnostic review and differential diagnosis. Arch Pathol Lab Med 2011; 135: 268-272.
 
eISSN:2084-9869
ISSN:1233-9687
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