ORIGINAL ARTICLE
Pulmonary coin lesion caused by Dirofilaria immitis – a report of two cases with a minireview of the literature
1
Faculty of Medicine, Institute of Pathology, University of Ljubljana, Ljubljana, Slovenia
Submission date: 2021-06-10
Final revision date: 2021-10-07
Acceptance date: 2021-10-31
Publication date: 2023-03-20
Corresponding author
Maja Jerše
Maja Jerše Institute of Pathology Faculty of Medicine University of Ljubljana Ljubljana, Slovenia
Maja Jerše Institute of Pathology Faculty of Medicine University of Ljubljana Ljubljana, Slovenia
Pol J Pathol 2022;73(4):352-358
KEYWORDS
TOPICS
ABSTRACT
Dirofilariasis is a rare zoonosis, transmitted from infested dogs or other carnivorous animals to humans via mosquitoes.
Two male patients with a solitary, peripheral, well-defined, coin-like pulmonary lesion in the right upper lobe were presented.
Rapid enlargement of the lesion within a few months suggested malignancy, resulting in surgical removal. Microscopic examination of the resected lung revealed necrotic circumscribed lesions with embolized parasites in the vessels.
Both parasites were females of the species Dirofilaria immitis. They represent the first reported cases of pulmonary dirofilariasis in Slovenia. Awareness of this entity is important in the differential diagnosis of pulmonary coin lesions.
Two male patients with a solitary, peripheral, well-defined, coin-like pulmonary lesion in the right upper lobe were presented.
Rapid enlargement of the lesion within a few months suggested malignancy, resulting in surgical removal. Microscopic examination of the resected lung revealed necrotic circumscribed lesions with embolized parasites in the vessels.
Both parasites were females of the species Dirofilaria immitis. They represent the first reported cases of pulmonary dirofilariasis in Slovenia. Awareness of this entity is important in the differential diagnosis of pulmonary coin lesions.
REFERENCES (36)
1.
De Campos JRM, Barbas CSV, Filomeno LTB, et al. Human pulmonary dirofilariasis. Analysis of 24 cases from São Paulo, Brazil. Chest 1997; 112: 729-733.
2.
Tsung SH, Liu CC. Human pulmonary dirofilariasis in Taiwan. J Formos Med Assoc 2003; 102: 42-45.
3.
Travis WD, Colby TV, Koss MN, et al. Non-neoplastic disorders of the lower respiratory tract. American registry of pathology, Washington 2002.
4.
Flieder DB, Moran CA. Pulmonary dirofilariasis: a clinicopathologic study of 41 lesions in 39 patients. Hum Pathol 1999; 30: 251-256.
5.
Dashiell GF. A case of dirofilariasis involving the lung. Am J Trop Med Hyg 1961; 10: 37-38.
6.
Pampiglione S, Del Maschio O, Pagan V, et al. Pulmonary dirofilariasis in man: a new Italian case. Review of the European literature. Parasite 1994; 1: 379-385.
7.
Pampiglione S, Rivasi F, Paolino S. Human pulmonary dirofilariasis. Histopathology 1996; 29: 69-72.
8.
Rena O, Leutner M, Casadio C. Human pulmonary dirofilariasis: uncommon cause of pulmonary coin-lesion. Eur J Cardiothorac Surg 2002; 22: 157-159.
9.
Patel D, Doi K. Images in medicine. Human pulmonary dirofilariasis. Med Health RI 2003; 86: 80.
10.
Haro A, Tamiya S, Nagashima A. A rare case of human pulmonary dirofilariasis with a growing pulmonary nodule after migrating infiltration shadows, mimicking primary lung carcinoma. Int J Surg Case Rep 2016; 22: 8-11.
11.
Dóczi I, Bereczki L, Gyetvai T, et al. Description of five dirofilariasis cases in South Hungary and review epidemiology of this disease for the country. Wien Klin Wochenschr 2015; 127: 696-702.
12.
Falidas E, Gourgiotis S, Ivopoulou O, et al. Human subcutaneous dirofilariasis caused by Dirofilaria immitis in a Greek adult. J Infect Public Health 2016; 9: 102-104.
13.
Chang IW, Gule MF. Human pulmonary dirofilariasis disguising as a lung tumour. Pol J Pathol 2018; 69: 432-434.
14.
Grapatsas K, Kayser G, Passlick B, et al.. Pulmonary coin lesion mimicking lung cancer reveals an unexpected finding: Dirofilaria immitis. J Thorac Dis 2018; 10: 3879-3882.
15.
Neafie RC, Connor DH, Meyers WM. Dirofilariasis. In: Binford CH, Connor DH (eds.). Pathology of tropical and extraordinary diseases. Armed Forces Institute of Pathology, Washington 1976, 391-396.
16.
Muro A, Genchi C, Cordero M, et al. Human Dirofilariasis in the European Union. Parasitol Today 1999; 15: 386-389.
17.
Cabrera ED, Carretón E, Morchón R, et al. The Canary Islands as a model of risk of pulmonary dirofilariasis in a hyperendemic area. Parasitol Res 2018; 117: 933-936.
18.
Anvari D, Narouei E, Daryani A, et al. The global status of Dirofilaria immitis in dogs: a systematic review and meta- analysis based on published articles. Res Vet Sci 2020; 131: 104-116.
19.
Portnoy LG. Dirofilariasis. In: Connor DH (ed.). Pathology of infectious diseases, Vol II. Appleton & Lange, Stamford 1997, 1391-1396.
20.
Ludlam KW, Jachowski LA, Otto GF. Potential vector of Dirofilaria immitis. J Am Vet Med Assoc 1970; 157: 1354-1359.
21.
Ellis DS, Rogers R, Bianco AE, et al. Intrauterine development of the microfilariae of Dipetalonema vitae. J Helminthol 1978; 52: 7-10.
22.
Johnstone C. Parasites and parasitic diseases of domestic animals. University of Pennsylvania, School of Veterinary Medicine and Merck 2000. http://cal.vet.upenn.edu/meria....
23.
Richer JK, Sakanari JA, Frank GR, et al. Dirofilaria immitis: proteases produced by third- and fourth-stage larvae. Exp Parasitol 1992; 75: 213-222.
24.
Abraham D, Grieve RB, Oaks JA. Dirofilaria immitis: molting process of third-stage larvae. Exp Parasitol 1990; 70: 314-322.
25.
Yoshimura EK, Wescott RB. Canine heartworm disease: a zoonosis of concern. Compend Contin Educ Pract Vet Small Animal Practice1989; 11: 575-578.
26.
Pampiglione S, Rivasi F, Canestri-Trotti G. Pitfalls and difficulties in histological diagnosis of human dirofilariasis due to Dirofilaria (Nochtiella) repens. Diagn Microbiol Infect Dis 1999; 34: 57-64.
27.
Boland JM, Pritt BS. Histopathology of parasitic infections of the lung. Semin Diagn Pathol 2017; 34: 550-559.
28.
Martínez S, Restrepo CS, Carrillo JA, et al. Thoracic manifestations of tropical parasitic infections: a pictorial review. Radiographics 2005; 25: 135-55.
29.
Martínez-Girón R, Esteban JG, Ribas A, et al. Protozoa in respiratory pathology: a review. Eur Respir J 2008; 32: 1354-1370.
31.
Hirano H, Kizaki T, Sashikata T, et al. Pulmonary dirofilariasis- clinicopathological study. Kobe J Med Sci 2002; 48: 79-86.
32.
Glickman LT, Grieve RB, Schantz PM. Serologic diagnosis of zoonotic pulmonary dirofilarisis Am J Med 1986; 80: 161-164.
33.
Sun S, Sugane K. Immunodiagnosis of human dirofilariasis by enzyme linked immunosorbent assay using recombinant DNA-derived fusion proteins. J Helminthol 1992; 66: 220-226.
34.
Perrera L, Perez-Arellano JL, Cordero M, et al. Utility of antibodies against a 22kDa molecule of Dirofilaria immitis in the diagnosis of human pulmonary dirofilariasis. Trop Med Int Health 1998; 3: 151-155.
35.
Latrofa MS, Weigl S, Dantas-Torres F, et al. A multiplex PCR for the simultaneous detection of species of filarioids infesting dogs. Acta Trop 2012; 122: 150-154.
36.
Favia G, Lanfrancotti A, Della Torre A, et al. Polymerase chain reaction – identification of Dirofilaria repens and Dirofilaria immitis. Parasitology 1996; 113: 567-571.
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| ISSN: | 1233-9687 |
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