ORIGINAL ARTICLE
Tumour thrombus consistency has no impact on survival in patients with renal cell carcinoma
Submission date: 2016-01-03
Final revision date: 2016-03-14
Acceptance date: 2016-03-25
Publication date: 2016-08-02
Pol J Pathol 2016;67(2):145-150
KEYWORDS
TOPICS
ABSTRACT
The prognosis of renal cell carcinoma (RCC) with venous tumour thrombus (VTT) is variable and not always possible to predict. The prognostic impact and independence of tumour thrombus-related factors including the recently introduced tumour thrombus consistency (TTC) on overall survival remain controversial. The aim of this study was to investigate the prognostic role of TTC in patients’ survival. We determined the tumour thrombus consistency (solid vs. friable) in a cohort of 84 patients with RCC and VTT who underwent nephrectomy with thrombectomy, and performed a retrospective evaluation of the patients’ data from the prospectively maintained database. A total of 45% of patients had solid thrombus (sTT) and 55% had friable thrombus (fTT). The venous tumour thrombus consistency was not predictive of overall survival. Further studies, preferably prospective and with a larger number of patients, are needed to validate the obtained results, as well as to evaluate the usefulness of tumour thrombus consistency in clinical practice for stratifying the risk of recurrence and planning further follow-up.
REFERENCES (15)
1.
Blute ML, Leibovich BC, Lohse CM, et al. The Mayo Clinic experience with surgical management, complications and outcome for patients with renal cell carcinoma and venous tumour thrombus. BJU Int 2014; 94: 33-41.
2.
Martínez-Salamanca JI, Linares E, González J, et al. Lessons learned from the International Renal Cell Carcinoma-Venous Thrombus Consortium (IRCC-VTC). Curr Urol Rep 2014; 15: 404.
3.
Woodruff DY, Van Veldhuizen P, Muehlebach G, et al. The perioperative management of an inferior vena caval tumor thrombus in patients with renal cell carcinoma. Urol Oncol 2013; 31: 517-521.
4.
Ljungberg B, Campbell SC, Choi HY, et al. The epidemiology of renal cell carcinoma. Eur Urol 2011; 60: 615-621.
5.
Kuroda N, Karashima T, Inoue K, et al. Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects. Pol J Pathol 2015; 66: 3-8.
6.
Al Otaibi M, Abou Youssif T, Alkhaldi A, et al. Renal cell carcinoma with inferior vena caval extention: impact of tumour extent on surgical outcome. BJU Int 2009; 104: 1467-1470.
7.
Wagner B, Patard JJ, Méjean A, et al. Prognostic value of renal vein and inferior vena cava involvement in renal cell carcinoma. Eur Urol 2009; 55: 452-459.
8.
Novara G, Ficarra V, Antonelli A, et al.; SATURN Project-LUNA Foundation. Validation of the 2009 TNM version in a large multi-institutional cohort of patients treated for renal cell carcinoma: are further improvements needed? Eur Urol 2010; 58: 588-595.
9.
Bertini R, Roscigno M, Freschi M, et al. The extent of tumour fat invasion affects survival in patients with renal cell carcinoma and venous tumour thrombosis. BJU Int 2011; 108: 820-824.
10.
Bertini R, Roscigno M, Freschi M, et al. Impact of venous tumour thrombus consistency (solid vs friable) on cancer-specific survival in patients with renal cell carcinoma. Eur Urol 2010; 60: 358-365.
11.
Weiss VL, Braun M, Perner S, et al. Prognostic significance of venous tumour thrombus consistency in patients with renal cell carcinoma (RCC). BJU Int 2014; 113: 209-217.
12.
Antonelli A, Sodano M, Sandri M, et al. Venous tumor thrombus consistency is not predictive of survival in patients with renal cell carcinoma: A retrospective study of 147 patients. Int J Urol 2015; 22: 534-539.
13.
Neves RJ, Zincke H. Surgical treatment of renal cancer with vena cava extension. Br J Urol 1987; 59: 390-395.
14.
Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC Cancer Staging Manual and the Future of TNM. Ann Surg Oncol 2010; 17: 1471-1474.
15.
Food and Drug Administration, Guidance for Industry Clinical Trial Endpoints for the Approval of Cancer Drugs and Biologics, (FDA, Rockville, MD, 2007), accessed from: mhttp://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM071590.pdf, on 01.01.2016.
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| eISSN: | 2084-9869 |
| ISSN: | 1233-9687 |
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