Synchronous distant metastasis is a major determinant of prognosis in colorectal adenocarcinoma, but its associations with routine histopathological parameters at individual metastatic sites remain incompletely understood. This retrospective study included 382 patients who underwent surgical resection for colorectal adenocarcinoma between 2006 and 2018. Clinicopathological parameters were evaluated in relation to synchronous distant metastasis overall and to liver, peritoneal, lung, and bone metastases using univariable analyses, exact tests where appropriate, and multivariable logistic regression. Synchronous distant metastasis was present in 83 patients (21.7%). In two separate multivariable models, lymph node metastasis, positive proximal/distal resection margin, low peritumoral lymphocytic infiltration, and perineural invasion were associated with higher odds of synchronous distant metastasis, whereas deficient mismatch repair (dMMR) status was associated with lower odds. Liver metastasis was associated with lymph node metastasis and positive proximal/distal resection margin, whereas dMMR status was associated with lower odds. In restricted exploratory models, tumor deposits and non-conventional histological subtype were associated with peritoneal metastasis, and tumor perforation was associated with lung metastasis. Bone metastasis was too infrequent for multivariable analysis. These organ-specific findings should be considered exploratory and require validation in larger independent cohorts.