LETTER TO THE EDITOR
Endometrial adenocarcinoma with gastrointestinal differentiation – a newly described entity, with morphologic diversity
1
Department of Pathology, University of Medicine, Pharmacy, Science and Technology of Targu Mures, Romania
2
Department of Cardiology, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Romania
3
Department of Pathology, Emergency Hospital, Targu Mures, Romania
4
Department of Gynecology and Obstetrics, University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Romania
Submission date: 2021-03-07
Acceptance date: 2021-03-14
Publication date: 2021-05-31
Pol J Pathol 2021;72(1):84-86
KEYWORDS
TOPICS
ABSTRACT
Gastrointestinal type of endometrial carcinoma is a newly described entity for which clearly defined diagnostic criteria have only recently been published. Among morphologic criteria, gastrointestinal mucinous adenocarcinoma of endometrium must not show a typical endometrioid component. We present a case with morphologic diversity, with areas showing gastric and intestinal differentiation as well as an endometrioid-like component. However, the endometrioid-like component not only did not show classic squamous metaplasia, but was also MUC6-positive, while the positivity for ER/PR was only focal. The recognition of gastric/gastrointestinal differentiation in endometrial carcinomas is best accomplished using both morphology and immunohistochemistry rather than either alone.
REFERENCES (12)
1.
Zheng W, Yang GC, Godwin TA, et al. Mucinous adenocarcinoma of the endometrium with intestinal differentiation: a case report. Hum Pathol 1995; 26: 1385-1388.
2.
Abiko K, Baba T, Ogawa M, et al. Minimal deviation mucinous adenocarcinoma (“adenoma malignum”) of the uterine corpus. Pathol Int 2010; 60: 42-47.
3.
Buell-Gutbrod R, Sung CJ, Lawrence WD, et al. Endometrioid adenocarcinoma with simultaneous endocervical and intestinal-type mucinous differentiation: report of a rare phenomenon and the immunohistochemical profile. Diagn Pathol 2013; 8: 128.
4.
Hino M, Yamaguchi K, Abiko K, et al. Magnetic resonance imaging findings and prognosis of gastric-type mucinous adenocarcinoma (minimal deviation adenocarcinoma or adenoma malignum) of the uterine corpus: two case reports. Mol Clin Oncol 2016; 4: 699-704.
5.
Rubio A, Schuldt M, Guarch R, et al. Pseudomyxoma-type invasion in gastrointestinal adenocarcinomas of endometrium and cervix: a report of 2 cases. Int J Gynecol Pathol 2016; 35: 118-122.
6.
McCarthy WA, Makhijani R, Miller K, et al. Gastric-type endometrial adenocarcinoma: report of two cases in patients from the United States. Int J Surg Pathol 2018; 26: 377-381.
7.
Wong RWC, Ralte A, Grondin K, et al. Endometrial gastric (gastrointestinal)-type mucinous lesions. Report of a series illustrating the spectrum of benign and malignant lesions. Am.
10.
Stolnicu S, Barsan I, Hoang L, et al. Diagnostic algorithmic proposal based on comprehensive immunohistochemical evaluation of 297 invasive endocervical adenocarcinomas. Am J Surg.
12.
Stolnicu S, Barsan I, Hoang L, et al. International endocervical adenocarcinoma criteria and classification (IECC): a new pathogenetic classification for invasive adenocarcinomas of the endocervix. Am J Surg Pathol 2018; 42: 214-226.
Share
RELATED ARTICLE
| eISSN: | 2084-9869 |
| ISSN: | 1233-9687 |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
