CASE REPORT
Lymphoepithelioma-like breast carcinoma
 
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Submission date: 2017-06-22
 
 
Final revision date: 2018-01-22
 
 
Acceptance date: 2018-01-27
 
 
Publication date: 2018-05-07
 
 
Pol J Pathol 2018;69(1):98-104
 
KEYWORDS
TOPICS
ABSTRACT
Nasopharyngeal lymphoepithelioma is an undifferentiated carcinoma in a dominated lymphoplasma-histiocyte stroma. Lymphoepithelioma-like carcinoma of the breast is the mammary counterpart of the lymphoepithelioma of the nasopharynx and is characterised by proliferation of poorly differentiated malignant cells within a prominent lymphoid infiltrate. It is a very rare primary carcinoma of the breast first reported in 1994 by Kumar and Kumar. Fewer than 40 cases have been reported in the English literature. In this manuscript a case of lymphoepithelioma-like carcinoma of the breast in a 57-year-old patient is reported along with a literature review on this rare entity.
REFERENCES (57)
1.
Schmincke A. On the subject of lymphoepithelial tumours [German]. Beitr Pathol Anat 1921; 68: 161-170.
 
2.
Regaud C, Reverchon L. A case of squamous epithelioma in the body of the superior maxillary [French]. Rev Laryngol Otol Rhinol 1921; 42: 369-378.
 
3.
Kumar S, Kumar D. Lymphoepithelioma-like carcinoma of the breast. Mod Pathol 1994; 7: 129-131.
 
4.
Cristina S, Boldorini R, Brustia F, et al. Lymphoepithelioma-like carcinoma of the breast: an unusual pattern of infiltrating lobular carcinoma. Virchows Arch 2000; 437: 198-202.
 
5.
Dadmanesh F, Peterse JL, Sapino A, et al. Lymphoepithelioma-like carcinoma of the breast: lack of evidence of Epstein-Barr virus infection. Histopathology 2001; 38: 54-61.
 
6.
Naidoo P, Chetty R. Lymphoepithelioma-like carcinoma of the breast with associated sclerosing lymphocytic lobulitis. Arch Pathol Lab Med 2001; 125: 669-672.
 
7.
Pes¸tereli HE, Erdogan O, Kaya R, et al. Lymphoepithelioma-like carcinoma of the breast. A newly recognized subtype of lobular carcinoma. APMIS 2002; 110: 447-450.
 
8.
Ilvan S, Celik V, Ulker Akyildiz E, et al. Lymphoepithelioma-like carcinoma of the breast: is it a distinct entity? Clinicopathological evaluation of two cases and review of the literature. Breast 2004; 13: 522-526.
 
9.
Sanati S, Ayala A, Middleton L. Lymphoepithelioma-like carcinoma of the breast: Report of a case mimicking lymphoma. Ann Diag Pathol 2004; 8: 309-315.
 
10.
Kurose A, Ichinohasama R, Kanno H, et al. Lymphoepithelioma- like carcinoma of the breast. Report of a case with the first electron microscopic study and review of the literature. Virchows Arch 2005; 447: 653-659.
 
11.
Saleh R, DaCamara P, Radhi J, et al. Lymphoepithelioma-like carcinoma of the breast mimicking nodular sclerosing Hodgkin’s lymphoma. Breast J 2005; 11: 353-354.
 
12.
Kulka J, Kovalszky I, Svastics E, et al. Lymphoepithelioma-like carcinoma of the breast: not Epstein-Barr virus-, but human papilloma virus-positive. Hum Pathol 2008; 39: 298-301.
 
13.
O’Sullivan-Mejia E, Idowu MO, Davis Masssey H, et al. Lymphoepithelioma-like carcinoma of the breast: diagnosis by core needle biopsy. Breast J 2009; 15: 658-660.
 
14.
Jeong AK, Park SB, Kim YM, et al. Lymphoepithelioma-like carcinoma of the breast. J Ultrasound Med 2010; 29: 485-488.
 
15.
Küçükzeybek BB, Bener S, Çalll AO, et al. Prognostic Significance of Bcl-2 and p53 Protein Expressions and Ki67 Proliferative Index in Diffuse Large B-cell Lymphoma. Turk J Haematol 2013; 30: 275-282.
 
16.
Trihia H, Siatra H, Gklisty H, et al. Lymphoepithelioma-like carcinoma of the breast: cytological and histological features and review of the literature. Acta Cytologica 2012; 56: 85-91.
 
17.
Nio Y, Tsuboi K, Tamaoki M, et al. Lymphoepithelioma like carcinoma of the breast: a case report with a special analysis of an association with human papilloma virus. Anticancer Res 2012; 32: 1435-1441.
 
18.
Dinniwell R, Hanna WM, Mashhour M, et al. Lymphoepithelioma-like carcinoma of the breast: a diagnostic and therapeutic challenge. Curr Oncol 2012; 19: 177-183.
 
19.
Top ÖE, Vardar E, Yagˇcl A, et al. Lymphoepithelioma-like carcinoma of the breast: a case report. Breast Health 2014; 10: 177-180.
 
20.
Abdou AG, Asaad NY. Lymphoepithelioma-like carcinoma of the breast: cytological, histological, and immunohistochemical characteristics. Diagn Cytopathol 2015; 43: 210-213.
 
21.
Suzuki I, Chakkabat P, Goicochea L, et al. Lymphoepithelioma-like carcinoma of the breast presenting as breast abscess. World J Clin Oncol 2014; 5: 1107-1112.
 
22.
Jansari TR, Gupta T, Trivedi PP, et al. Lymphoepithelioma-like carcinoma of the breast: a case report. Ann Pathol Lab Med 2015; 2: C235-C238.
 
23.
Nankin NL, Gondusky CJ, Abasolo PA, et al. Lymphoepithelioma like carcinoma of the breast. Radiol Case Rep 2015; 10: 963.
 
24.
Herrera-Goepfert R, Caro-Sánchez C, Maafs-Molina E. Lymphoepithelioma-like carcinoma of the breast: a singular morphological pattern with an expected outcome. Austin J Clin Case Rep 2016; 3: 1102.
 
25.
Shet T, Pai T, Shetty O, Desai S. Lymphoepithelioma-like carcinoma of breast- evaluation for Epstein-Barr virus - encoded RNA, human papillomavirus, and markers of basal cell differentiation. Ann Diagn Pathol 2016; 25: 42-47.
 
26.
Kon S, Kasai K, Tsuzuki N, et al. Lymphoepithelioma-like carcinoma of rectum: possible relation with EBV. Pathol Res Pract 2001; 197: 577-582.
 
27.
Yamada T, Tatsuzawa Y, Yagi S, et al. Lymphoepitheliomalike esophageal carcinoma: report of a case. Surg Today 1999; 29: 542-544.
 
28.
Tamas EF, Nielsen ME, Schoenberg MP, et al. Lymphoepithelioma-like carcinoma of the urinary tract: a clinicopathological study of 30 pure and mixed cases. Mod Pathol 2007; 20: 828-834.
 
29.
Blasi MA, Ventura L, Laguardia M, et al. Lymphoepithelioma-like carcinoma involving the lacrimal gland and infiltrating the eyelids. Eur J Ophthalmol 2011; 21: 320-323.
 
30.
Bloching M, Hinze R, Berghaus A. Lymphepithelioma-like carcinoma of the lacrimal gland. Eur Arch Otorhinolaryngol 2000; 257: 399-401.
 
31.
Andryk J, Freije JE, Schultz CJ, et al. Lymphoepithelioma of the larynx. Am J Otolaryngol 1996; 17: 61-63.
 
32.
Lee W. Intrahepatic lymphoepithelioma-like cholangiocarcinoma not associated with Epstein-Barr virus: a case report. Case Rep Oncol 2011; 4: 68-73.
 
33.
Nemolato S, Fanni D, Naccarato AG, et al. Lymphoepithelioma-like hepatocellular carcinoma: a case report and a review of the literature. World J Gastroenterol 2008; 14: 4694-4696.
 
34.
Ho JC, Wong MP, Lam WK. Lymphoepithelioma-like carcinoma of the lung. Respirology 2006; 11: 539-545.
 
35.
Krishnamurthy S, Lanier AP, Dohan P, et al. Salivary gland cancer in Alaskan natives, 1966–1980. Hum Pathol 1987; 18: 986-996.
 
36.
Hamilton-Dutoit SJ, Therkildsen MH, Neilsen NH, et al. Undifferentiated carcinoma of the salivary gland in Greenlandic Eskimos: demonstration of Epstein–Barr virus DNA by in situ nucleic acid hybridization. Hum Pathol 1991; 22: 811-815.
 
37.
Saemundsen AK, Albeck H, Hansen JP, et al. Epstein-Barr virus in nasopharyngeal and salivary gland carcinomas of Greenland Eskimos. Br J Cancer 1982; 46: 721-728.
 
38.
Saw D, Lau WH, Ho JH, et al. Malignant lymphoepithelial lesion of the salivary gland. Hum Pathol 1986; 17: 914-923.
 
39.
Kumar KL, Chayanika K, Ahmed A, et al. Lymphoepithelioma like carcinoma of orbital adnexa: A rare case report. Inter.
 
40.
J Med Res Health Sci 2015; 4: 702-704.
 
41.
Welch PQ, Williams SB, Foss RD, et al. Lymphoepithelioma-like carcinoma of head and neck skin: a systematic analysis of 11 cases and review of literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011; 111: 78-86.
 
42.
Herath CH, Chetty R. Epstein–Barr virus-associated lymphoepithelioma-like gastric carcinoma. Arch Pathol Lab Med 2008; 132: 706-709.
 
43.
Nicolato A, Ferraresi P, Bontempini L, et al. Multiple brain metastases from “lymphoepithelioma-like” thymic carcinoma: a combined stereotacticradiosurgical approach. Surg Neurol 2001; 55: 232-234.
 
44.
Shek TW, Luk IS, Ng IO, et al. Lymphoepithelioma-like carcinoma of the thyroid gland: lack of evidence of association with Epstein-Barr virus. Hum Pathol 1996; 27: 851-853.
 
45.
Satyanarayana S, Pathak SD, Saraswat V, et al. Tracheal lymphoepithelioma-like carcinoma: a case report. Indian J Cancer 2002; 39: 112-115.
 
46.
Terai A, Terada N, Ichioka K, et al. Lymphoepithelioma-like carcinoma of the ureter. Urology 2005; 66: 1109.
 
47.
Porcaro AB, Gilioli E, Migliorini F, et al. Primary lymphoepithelioma-like carcinoma of the urinary bladder: report of one case with review and update of the literature after a pooled analysis of 43 patients. Int Urol Nephrol 2003; 35: 99-106.
 
48.
Kaul R, Gupta N, Sharma J, et al. Lymphoepitheliomalike carcinoma of the uterine cervix. J Cancer Res Ther 2009; 5: 300-301.
 
49.
McCluggage WG. Lymphoepithelioma-like carcinoma of the vagina. J Clin Pathol 2001; 54: 964-965.
 
50.
Niu W, Heller DS, D’Cruz C. Lymphoepithelioma-like carcinoma of the vulva. J Low Genit Tract Dis 2003; 7: 184-186.
 
51.
Slukvin II, Schink JC, Warner TF. Lymphoepithelioma-like carcinoma of the vulva: a case report. J Low Genit Tract Dis 2003; 7: 136-139.
 
52.
Iezzoni JC, Gaffey MJ, Weiss LM. The role of Epstein-Barr Virus in lymphoepithelioma-like carcinomas. Am J Clin Pathol 1995; 103: 308-315.
 
53.
Ribassin-Majed L, Marguet S, Lee AW, et al. What is the best treatment of locally advanced nasopharyngeal carcinoma? An individual patient data network meta-analysis. J Clin Oncol 2017; 35: 498-505.
 
54.
Early Breast Cancer Trialists’ Collaborative Group (EBCTCG), Peto R, Davies C, Godwin J, et al. Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials. Lancet 2012; 379: 432-444.
 
55.
Ridolfi RL, Rosen PP, Port A, et al. Medullary carcinoma of the breast: a clinicopathologic study with 10 year follow-up. Cancer 1977; 40: 1365-1385.
 
56.
Lakhani SR, Ellis IO, Schnitt SJ, et al. WHO Classification of Tumors of the Breast. In: Carcinomas with medullary features. Jacquemier J, Reis-Filho JS, Lakhani SR, Rakha E (eds). 4th ed. International Agency for Research on Cancer, Lyon 2012; 46-47.
 
57.
Ohtani H, Mori-Shiraishi K, Nakajima M, et al. Defining lymphocyte-predominant breast cancer by the proportion of lymphocyte-rich stroma and its significance in routine histopathological diagnosis. Pathol Int 2015; 65: 644-651.
 
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